Sunday, October 17, 2010

How many published studies are actually true?

I’d like to point readers to this excellent new article in The Atlantic on meta-researcher John Ioannidis. Ioannidis is building quite the career on exposing the multiple biases in medical research. He has taken a field to task publishing papers with shy titles such as “Why most research findings are false”. He is rapidly becoming a personal hero of mine.

Ioannidis has examined and formally quantified research biases at all levels of “production”: in which questions are being asked, in the design of experiments, in the analysis of these experiments, and in the presentation and interpretation of the results. “At every step in the process, there is room to distort results, a way to make a stronger claim or to select what is going to be concluded,” says Ioannidis in the article. “There is an intellectual conflict of interest that pressures researchers to find whatever it is that is most likely to get them funded.”

While I have examined some of these biases for both general research and fMRI experiments, it’s worth noting that in the context of medical research, the stakes are even higher as they affect patient care. It is also unfortunate that medical studies are, according to Ioannidis, more likely to contain bias as there are stronger financial interests vested in the results, compared to cognitive neuroscience. 

An unfortunate result of the competitive research environment is a lack of replication of scientific results. Although replication is the gold standard of a result’s truth, there is little acknowledgment, and thus little motivation for researchers to do this, except for the most bold of claims. Without replication, bias in research increases. However, even when a failure to replicate a major study is published, it often gets very little attention. A case in point is the failure to replicate the “Mozart effect”: the finding that listening to 10 minutes of a Mozart sonata significantly increased participants’ performance on a spatial reasoning test. A quick Googling of “Mozart effect” will show you several companies selling you Mozart recordings to increase your child’s IQ, despite the failure to replicate.

It is very easy to get discouraged by this, after all, science should be a science, right? Ioannidis seems less discouraged, and reminds us of the following: “Science is a noble endeavor, but it’s also a low-yield endeavor… I’m not sure that more than a very small percentage of medical research is ever likely to lead to major improvements in clinical outcomes and quality of life. We should be very comfortable with that fact.”

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